Why Resistance Training & Other Muscle Building Activities Are Good For The Brain & The Prevention of Dementia.
Likely you’ve heard about the importance of muscle strengthening in the prevention of bone health. What is less known, however, is the relationship between the health of our muscles and the health of our brain. In this newsletter, I’ll address:
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How Our Microbiome Influences Our Brain Development, Sense of Well-Being, Mood, Cognition, Stress Tolerance, Social Engagement, Aging Process & Conditions Such as ADHD, Autism & Alzheimer's.
Our gut microbiome forms a dynamic ecosystem of trillions of microbes, including bacteria, viruses, archaea, and fungi, in thousands of species—many of which have existed long before humans. While research into the microbiome has gained traction only in the past twenty years, our ancestors recognized the connection between digestion and emotions, mood, and behavior. Historical practices like fecal transplants date back to Ancient Greece and 4th century China. By the 18th century, the concept of the gut-brain axis was already recognized, and in the 19th century, physicians acknowledged the influence of the gastrointestinal (GI) tract on mental well-being. However, the 20th century saw a regression in this understanding, with scientists asserting that it was the mind affecting the gut instead. It wasn't until the 21st century that we reconciled these views, acknowledging that both can be true. The brain impacts the gut through the autonomic nervous system, while the gut influences the brain through its microbial inhabitants. So, how exactly does the gut microbiome affect the brain beyond its role in nutrient absorption? This influence is largely through three primary mechanisms. 
Passive & Active "Bottom Up" Approaches to Relax, Improve Mood, Focus & Sleep, Decrease Pain & Muscle Tightness, Improve Social Communication, Lower Inflammation & More
The vagus nerve is truly remarkable. It helps us relax, focus, engage socially, and maintain a positive mood. By countering the body’s stress response, it lowers inflammation and communicates with key organs in the digestive, respiratory, and cardiovascular systems. The vagus nerve also plays a crucial role in social interactions, unconsciously assessing the safety of others. Ever feel uncertain about someone you just met, without knowing why? That’s your vagus nerve—your "sixth sense"—sending signals your conscious mind might miss. The best part? We can actively support our vagus nerve. If you’re dealing with stress, mood issues, trouble focusing, sleep problems, or chronic pain, you can tap into the power of the vagus. This also applies to psychiatric conditions, headaches, autoimmune diseases, heart and lung issues, digestive problems, and even cancer. In last week's paid newsletter, I covered how to recognize vagus nerve dysfunction and why it might not be functioning optimally. In this edition, I’ll explore ways to stimulate and "exercise" the vagus nerve, offering immediate calming effects and long-term resilience. Regular practice can raise stress tolerance and help us recover from stress more quickly. 
Data, Contributing Factors, Undermethylation, When Strengths Relate to Vulnerabilities, Self Reliance, a Medical Culture That Keeps Physicians From Seeking Help & What Can Be Done
It’s easy to overlook that medical professionals are vulnerable to stress, burnout, and both physical and mental health issues. Despite the expectation that they remain well, physicians experience higher rates of depression, and the rate of physician suicide is twice that of the general population. In this newsletter, I’ll explore how biochemical and environmental factors play a role in both the strengths and vulnerabilities of doctors. While the focus is on physicians, much of what I’ll discuss also applies to other medical professionals and caregivers.
Key topics include:
Understanding Smart Meters and EMF Exposure: Insights from Eric Windheim
Eric Windheim, BA, BBEC, EMRS, RFSO, is a Certified Electromagnetic Radiation Specialist and Building Biology Environmental Consultant. As the founder of Windheim Solutions, he specializes in inspecting, testing, and remediating harmful electromagnetic fields (EMFs). In this episode, we explore the topic of smart meters—digital devices that measure real-time electricity usage and wirelessly transmit this data to utility companies. Smart meters are also sometimes used for gas and water monitoring.
Smart meters primarily emit radio frequencies, one of the four harmful types of electromagnetic fields, alongside electric fields, magnetic fields, and dirty electricity. EMF exposure has been linked to a variety of brain symptoms, such as insomnia, memory issues, irritability, depression, personality changes, inattention, fatigue, confusion, headaches, tinnitus, dizziness, numbness, and tingling.
Problematic EMFs impact the brain in multiple ways, contributing to oxidative stress, neurotoxicity, immune system disruption, hormonal imbalances, microbiome disturbances, and compromising the blood-brain barrier. EMFs can even elevate blood sugar levels. Fortunately, there are numerous ways to reduce exposure. In this newsletter: Eric shares:
We discuss:
From the Walsh Research Institute’s original data.
By Courtney Snyder, MD
A Conversation About High Copper, Low Zinc, Pyrrole Disorder & Methylation Imbalances - Symptoms, Traits, Testing & Treatment I recently had the pleasure of joining Annika Taylor, a holistic health practitioner, on the Nourished By Nature: Mind Body Wellness Podcast. After sharing my journey into holistic psychiatry and defining what it means, Annika and I explored the following topics:
We also discussed a recent finding by Dr. Walsh that undermethylation is on the rise in the population, while overmethylation appears to be decreasing. Related Resources: Annika Taylor - nourishedbynature.com Walsh Research Institute For links to specific topics address see links in the description above.
In this video and podcast episode, I dive into pyrrole disorder, a common nutrient imbalance linked to various brain-related conditions affecting both adults and children. Elevated levels of Hydroxyhemopyrrolin-2-one (HPL) in the urine, often referred to as “pyrroles,” have been connected to conditions such as depression, anxiety, schizophrenia, bipolar disorder, autism, ADHD, learning disorders, substance use disorders, and even violent behavior.
In this discussion, I cover:
This episode is essential for understanding the role pyrrole disorder plays in mental health and how addressing it can lead to significant improvements in well-being. Related Resources
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Medical Disclaimer: This newsletter is for educational purposes and not intended or implied to be a substitute for professional medical advice, diagnosis or treatment for either yourself or others, including but not limited to patients that you are treating (if you are a practitioner). Consult your own physician for any medical issues that you may be having.
Common symptoms and traits associated with undermethylation. Having all of these is not necessary.
By Courtney Snyder, MD
Approximately 70% of individuals with a mental health condition have a methylation imbalance, with the majority being undermethylated rather than overmethylated.
For those unfamiliar with methylation, it is a crucial biochemical process in which a methyl group is added to specific molecules. This process significantly affects gene expression, detoxification capabilities, and susceptibility to inflammation. When methylation is out of balance, it can contribute to a range of chronic health problems, including cardiovascular disease, autoimmune disorders, cancer, and various psychiatric conditions.
Undermethylation is particularly prevalent among those with mental health conditions. Here's a breakdown of the incidence of undermethylation in different groups:
Undermethylation is the most common biochemical imbalance found in individuals with depression, highlighting its significance in mental health.
Additional Resources
Nutrient Power - Heal Your Biochemistry and Heal Your Brain by William Walsh, PhD Walsh Research Institute - Walsh trained practioners Lunch with Dr. William Walsh - His Story, Discoveries & the Future of Nutrient-Based Psychiatry Epigenetics, Methylation, MTHFR & the Brain, Made Easy...er Undermethylation & Strengthening the Right Brain in a Left Brain World  “Mary Poppins Goes To the Beach” -Made by combining pieces from 3 collages in my Impermanent Art Series. By Courtney Snyder, MD
Half of my work day is spent honing in on details. For each person I evaluate and treat, I’m considering multiple symptoms, lab data, contributing factors, and treatment interventions. Left unchecked, this amount of detail hurts my brain - figuratively and literally. This type of work might be considered “left brain“ and appealing to someone who is “undermethylated,” which I am. The other half of my work day is involved with addressing how, from a spiritual perspective, we:
By spiritual, I mean our inner life. My writing and teaching about the intersection between neuroplasticity and spirituality is essentially about how we exercise those parts of the brain that relate to that inner work. Instead of honing in on details, this is about pulling back and looking at the bigger picture of our lives and our humanity. This right brain work feels good.  "Light Showers on Tidy Town" paper, acrylic on 24 x 48" canvas "Inspired by the coastal towns of Ireland." By Courtney Snyder
One of the challenges of writing blog posts that explore root causes of brain related symptoms is that what we are learning is constantly evolving. There's so much we still and will never know. Another challenge - everything is interconnected. The best I can do is to write about these root causes separately. While some contributing factors can occur in parallel, one condition is often leading to other downstream conditions that themselves contribute to things like depressed mood, anxiety, mood swings, brain fog/inattention and so forth. Mold toxicity is a perfect example. It can contribute to Pyrrole Disorder due the stress it puts on the body. It can lead to elevated copper by overwhelming one of the antioxidants in the body that regulates copper. Because it interferes with the immune system, it can lead to a susceptibility to candida/yeast, Lyme and its co-infections. It also frequently worsens mast cell activation (see last post). I consider it a root of the roots. In my daily work, I find mold toxicity to be very common. Here’s why - Lunch with Dr. William Walsh - His Story, Discoveries & the Future of Nutrient-Based Psychiatry7/1/2016 
Courtney Snyder, MD
I first met Dr. Walsh in the fall of 2014, at his second physician training course here in the US. At the time, I was uncertain how useful nutrients would be in my psychiatric practice. What I learned seemed too good to be true. Upon returning home, I gradually began evaluating and treating specific nutrient imbalances in adults and children with depression, ADHD, anxiety, bipolar disorder, autism and other conditions. To my repeated surprise, most patients - children and adults alike improved… significantly - some dramatically, including those whose symptoms had failed to respond to other treatments. 
Courtney Snyder, MD
Purpose, Healing and Happiness Whatever language, symbolism or religious framework we use or try not to use, many of us believe there's a reason each of us are here ...at this time, in this place and with these people. Though I think a lot about the details of health, I fall short on the bigger picture of healing if I forget that our wellbeing depends on much more, not the least of which is having a deep sense of purpose in our lives. Purpose can energize us. It is a reason to do the hard work; to get out of bed. It lowers stress and it’s associated physiologic responses. Futility is stressful. So is incongruence - the mismatch between our natural abilities and passions and what we’re actually doing. With purpose comes a clarity about what and with whom we want to spend our time. 
By Courtney Snyder, MD
Historically we've considered mental health and illness as coming from either one's life experiences or coming from one's genetics or biology. We've mistakenly considered the the brain separate from the rest of the body. We are more interconnected than those outdated views suggest. Our physical health impacts our brain health. Likewise, we experience emotions (fear, anger, sadness, and joy) not only in our brains, but in our bodies. Emotions influence our brain's biochemistry, and our biochemistry impacts our emotions, bodies and how we experience our lives. PYRROLE DISORDER A perfect example of this is Pyrrole Disorder - an inborn error of pyrrole chemistry. Those who are affected make an excessive amount of this metabolite. Pyrroles themselves are not a problem and do not cause disease. We all have them. They do however, bind Vitamin B6 and Zinc. When pyrroles leave the body (through urine), they take some B6 and zinc with them. This is not a problem either. The problem comes when pyrroles are being overproduced for genetic reasons or because of physical or emotional stress. This can lead to severe B6 and zinc deficiencies. 
Courtney Snyder, MD
Before I delve at length into the amazing process of methylation and its impact on personality and mental health, I'll lay some groundwork. For those who don't need or want such background, I've tried to make it easy for you to hit the highlights or jump ahead to your own starting point. 
Courtney Snyder, MD
Psychiatric medications are a good thing ...for a lot of people....at least at this time in the history of medicine. They save lives and alleviate suffering and pain.  Courtney Snyder, MD
Who knew...copper, the essential trace element important in the synthesis of neurotransmitters, respiration, immune function, energy metabolism and growth, could wreak so much havoc on the mind and body? I never gave much thought to copper until it presented itself to me in the most delightful way...a dream of a copper tiled ceiling - the most memorable dream I've had. Copper ... "associated with the goddess Aphrodite/Venus in mythology and alchemy, ...symbolic of love, balance, feminine beauty and artistic creativity." So taken with this dream, I painted a mantel copper. We eventually moved and left that copper mantel and dream behind. Ten years later copper resurfaced at the Walsh Research Institute where Dr. William Walsh was teaching about copper overload - one of the most common biochemical imbalances found in brain related disorders. "In most persons, blood copper levels are kept in a narrow range through the action of metallothionein, ceruloplasmin, as well as other proteins. Unfortunately, many persons have a genetic inability to regulate copper levels and a serious copper overload can result." - William Walsh, PhD. |
Courtney Snyder, MDFor anyone experiencing brain symptoms. This blog (and weekly newsletter) is your guide to demystifying root causes and learning about surprising paths to healing. From a holistic - functional adult and child psychiatrist dedicated to helping people heal and thrive. Categories
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