|
Undermethylation has been associated with depression, ADHD, delusional psychosis, autism, dementia, eating disorders, and a number of other brain related symptoms. In this conversation Dr. Judy Tsafrir and I discuss: the important role of methylation the consequences of undermethylation personality traits and symptoms associated diagnoses evaluation and testing treatment and dietary recommendations controversies related to undermethylation.
2 Comments
12/1/2020 07:32:45 pm
Thank you for this interesting conversation. I’m wondering if you are aware of research linking Sensory Processing Sensitivity (aka High Sensitive Trait) with undermethylation? 12/2/2020 05:57:31 am
Hi Pamela. Great question. I am not aware of any specific research. Sensory Processing Sensitivity, in my opinion, is likely secondary a weakness in 21 hydroxylase - an enzyme involved in stress hormone pathways. Theoretically, a weakness here could result in someone's brain development being "wired for danger," often along with unusual abilities (and heightened sensitivity). This inherent increased stress response can make someone more susceptible to inflammation - specifically mast cell activation - which involves immune cells releasing histamine and other inflammatory mediators. Because methylation (which involves other genes) is part of what breaks down histamine, if someone is undermethylated and also seeming prone to mast cell activation (because of this stress response), they will experience the effects of inflammation more than someone who has one of these variables. Also undermethylation would make someone more susceptible to toxicity which again could trigger a more exaggerated stress response in someone with a seeming 21 hydroxylase weakness. My post on RCCX theory talks more about this (or the RCCX website). Thanks for your question, Your comment will be posted after it is approved.
Leave a Reply. |
Available on Apple Podcast, Spotify and most listening Platforms.Archives
June 2021
Categories
All
|
RSS Feed